diff --git a/os/gcache/gcache_adapter_memory_data.go b/os/gcache/gcache_adapter_memory_data.go
index ddd0c5fae86..8e0037036f0 100644
--- a/os/gcache/gcache_adapter_memory_data.go
+++ b/os/gcache/gcache_adapter_memory_data.go
@@ -182,12 +182,13 @@ func (d *memoryData) SetMap(data map[interface{}]interface{}, expireTime int64)
 }
 
 func (d *memoryData) SetWithLock(ctx context.Context, key interface{}, value interface{}, expireTimestamp int64) (interface{}, error) {
-	d.mu.Lock()
-	defer d.mu.Unlock()
 	var (
 		err error
 	)
-	if v, ok := d.data[key]; ok && !v.IsExpired() {
+	d.mu.Lock()
+	v, ok := d.data[key]
+	d.mu.Unlock()
+	if ok && !v.IsExpired() {
 		return v.v, nil
 	}
 	f, ok := value.(Func)
@@ -203,7 +204,9 @@ func (d *memoryData) SetWithLock(ctx context.Context, key interface{}, value int
 			return nil, nil
 		}
 	}
+	d.mu.Lock()
 	d.data[key] = memoryDataItem{v: value, e: expireTimestamp}
+	d.mu.Unlock()
 	return value, nil
 }
 
diff --git a/os/gcache/gcache_z_unit_issue_test.go b/os/gcache/gcache_z_unit_issue_test.go
new file mode 100644
index 00000000000..67bf1630182
--- /dev/null
+++ b/os/gcache/gcache_z_unit_issue_test.go
@@ -0,0 +1,89 @@
+package gcache_test
+
+import (
+	"context"
+	"testing"
+	"time"
+
+	"github.com/gogf/gf/v2/os/gcache"
+	"github.com/gogf/gf/v2/test/gtest"
+)
+
+// https://github.com/gogf/gf/issues/4145
+func Test_Issue4145(t *testing.T) {
+	gtest.C(t, func(t *gtest.T) {
+		var (
+			ctx        = context.Background()
+			cache      = gcache.New()
+			cacheKey1  = "GetTest-1"
+			cacheKey2  = "GetTest2-1"
+			cacheValue = "123456789"
+		)
+
+		// 定义需要测试的闭包函数
+		getTestCached := func(ctx context.Context) (*string, error) {
+			v, err := cache.GetOrSetFuncLock(ctx, cacheKey1, func(ctx context.Context) (interface{}, error) {
+				str := cacheValue
+				return &str, nil
+			}, 1*time.Minute)
+
+			if err != nil {
+				return nil, err
+			}
+
+			var res *string
+			if err := v.Struct(&res); err != nil {
+				return nil, err
+			}
+			return res, nil
+		}
+
+		getTest2Cached := func(ctx context.Context) (*string, error) {
+			v, err := cache.GetOrSetFuncLock(ctx, cacheKey2, func(ctx context.Context) (interface{}, error) {
+				// 内部调用 getTestCached
+				return getTestCached(ctx)
+			}, 1*time.Minute)
+
+			if err != nil {
+				return nil, err
+			}
+
+			var res *string
+			if err := v.Struct(&res); err != nil {
+				return nil, err
+			}
+			return res, nil
+		}
+
+		// 测试用例
+		// 第一次获取应该走实际逻辑
+		value, err := getTestCached(ctx)
+		t.AssertNil(err)
+		t.Assert(*value, cacheValue)
+
+		// 第二次获取应该走缓存
+		v, err := cache.Get(ctx, cacheKey1)
+		t.AssertNil(err)
+		t.Assert(v, cacheValue)
+
+		// 测试嵌套缓存调用
+		value, err = getTest2Cached(ctx)
+		t.AssertNil(err)
+		t.Assert(*value, cacheValue)
+
+		// 验证二级缓存
+		v, err = cache.Get(ctx, cacheKey2)
+		t.AssertNil(err)
+		t.Assert(v, cacheValue)
+
+		// 清理所有缓存
+		_, err = cache.Remove(ctx, cacheKey1, cacheKey2)
+		t.AssertNil(err)
+
+		// 验证清理结果
+		v1, _ := cache.Get(ctx, cacheKey1)
+		v2, _ := cache.Get(ctx, cacheKey2)
+		t.Assert(v1, nil)
+		t.Assert(v2, nil)
+	})
+}