CITATION.cff

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title: Repertoire comparison of the B-cell receptor-encoding loci in humans and rhesus
  macaques by next-generation sequencing
authors:
- family-names: Vigdorovich
  given-names: Vladimir
  orcid: "https://orcid.org/0000-0003-4195-4858"
- family-names: Oliver
  given-names: Brian G
- family-names: Carbonetti
  given-names: Sara
- family-names: Dambrauskas
  given-names: Nicholas
- family-names: Lange
  given-names: Miles D
- family-names: Yacoob
  given-names: Christina
- family-names: Leahy
  given-names: Will
- family-names: Callahan
  given-names: Jonathan
- family-names: Stamatatos
  given-names: Leonidas
- family-names: Sather
  given-names: D Noah
doi: https://doi.org/10.1038/cti.2016.42
url: https://pubmed.ncbi.nlm.nih.gov/27525066/
abstract: Rhesus macaques (RMs) are a widely used model system for the study of vaccines,
  infectious diseases and microbial pathogenesis. Their value as a model lies in their
  close evolutionary relationship to humans, which, in theory, allows them to serve as
  a close approximation of the human immune system. However, despite their prominence
  as a human surrogate model system, many aspects of the RM immune system remain ill
  characterized. In particular, B cell-mediated immunity in macaques has not been
  sufficiently characterized, and the B-cell receptor-encoding loci have not been
  thoroughly annotated. To address these gaps, we analyzed the circulating heavy- and
  light-chain repertoires in humans and RMs by next-generation sequencing. By
  comparing V gene segment usage, J-segment usage and CDR3 lengths between the two
  species, we identified several important similarities and differences. These
  differences were especially notable in the IgM(+) B-cell repertoire. However, the
  class-switched, antigen-educated B-cell populations converged on a set of similar
  characteristics, implying similarities in how each species responds to antigen. Our
  study provides the first comprehensive overview of the circulating repertoires of
  the heavy- and light-chain sequences in RMs, and provides insight into how they may
  perform as a model system for B cell-mediated immunity in humans.