Synergistic effect prediction result filter

run_synlethal_analysis.py

Takes output file from "synthetic lethal" tool (should be synergistic effect predictions instead of synthetic lethality) and applies the following filters to narrow down for the most synergistic pairs.

Usage

python run_synlethal_analysis.py [output file from synthetic lethal tool] > [output file name]

Notes

By default, it assumes the 'effected nodes' of interest are only the following:

• 419195 p-T19,S20-MRLC-smooth muscle/non-muscle myosin II
• 5668934 p-T19-MRLC-smooth muscle/non-muscle myosin II

To obtain results with the filters:

• Individual effects of both genes must differ < 0.10
• The smallest individual effect of the two nodes must be < 0.95

Print contents of syn_lethal dictionary (currently commented out at the bottom)

for pair in syn_lethal: ...

To obtain results with a comparison of the 'expected' and 'observed':

Note: none of the filters above will be added but script can be changed to include filters as well

Print contents of obs_vs_exp dictionary (currently will print)

for pair in obs_vs_exp: ...